Here is a great thought from the popular devotional writer Henri Nouwen. As people we can easily reject ourselves. If it gets out of hand it can lead to self-destructive behaviors. Nouwen shares the difference between self-rejection and humility.
"One of the greatest dangers in the spiritual life is self-rejection. When we say, "If people really knew me, they wouldn't love me," we choose the road toward darkness. Often we are made to believe that self-deprecation is a virtue, called humility. But humility is in reality the opposite of self-deprecation. It is the grateful recognition that we are precious in God's eyes and that all we are is pure gift. To grow beyond self-rejection we must have the courage to listen to the voice calling us God's beloved sons and daughters, and the determination always to live our lives according to this truth."